Yeni bir ara\u015ft\u0131rma, GLP-1 grubu kilo verme ve diyabet ila\u00e7lar\u0131n\u0131 kullanan ki\u015filerin k\u00fc\u00e7\u00fck bir k\u0131sm\u0131nda, nadir g\u00f6r\u00fclen ciddi bir beyin hastal\u0131\u011f\u0131 tespit edildi\u011fini ortaya koydu. \u0130srail merkezli bir \u00e7al\u0131\u015fmada, ABD G\u0131da ve \u0130la\u00e7 \u0130daresi'nin (FDA) istenmeyen yan etki raporlar\u0131 ve ilgili literat\u00fcr\u00fc incelenerek 2023-2024'te yakla\u015f\u0131k 15 Wernicke sendromu (Wernicke ensefalopatisi) vakas\u0131 tespit edildi.<\/p>\n
Uzmanlar, bu hastal\u0131\u011f\u0131n yayg\u0131n olmad\u0131\u011f\u0131n\u0131 vurgulad\u0131. \u00c7al\u0131\u015fmada yer almayan \u015eikago merkezli klinisyen Karthik Achari, Fox News Digital'a yapt\u0131\u011f\u0131 a\u00e7\u0131klamada, "Ara\u015ft\u0131rmac\u0131lar istenmeyen yan etki raporlar\u0131n\u0131 ve t\u0131bbi literat\u00fcr\u00fc inceledi\u011finde, GLP-1 ila\u00e7lar\u0131n\u0131 kullanan ki\u015filerde az say\u0131da (15 adet) Wernicke sendromu vakas\u0131 buldu" dedi.<\/p>\n
Bu say\u0131, s\u00f6zkonusu ila\u00e7lar\u0131 kullanan milyonlarca insan aras\u0131ndan \u00e7\u0131k\u0131yor. Dolay\u0131s\u0131yla bu durum nadir g\u00f6r\u00fcl\u00fcyor. Achari, "Yine de bu durum ger\u00e7ek, ciddi ve arkas\u0131ndaki mekanizma mant\u0131kl\u0131" diye ekledi. \u00c7al\u0131\u015fmadaki 15 vakan\u0131n \u00e7o\u011fu, ila\u00e7lara ba\u011fl\u0131 olarak kusma, ishal ve i\u015ftah kayb\u0131 gibi gastrointestinal yan etkiler ya\u015fayan ki\u015filerde g\u00f6r\u00fcld\u00fc.<\/p>\n
Sinir sistemini ve beyin sa\u011fl\u0131\u011f\u0131n\u0131 destekleyen B1 vitamini, yaln\u0131zca g\u0131dalar ve takviyeler yoluyla al\u0131nabiliyor. Ara\u015ft\u0131rmac\u0131lar, "Hastalar\u0131n \u00e7o\u011fu [15 ki\u015fiden 13'\u00fc] kilo kayb\u0131, kusma, i\u015ftah kayb\u0131 veya yetersiz beslenme gibi gastrointestinal belirtiler bildirdi" ifadelerini kulland\u0131.<\/p>\n
Bu yaz yap\u0131lan Gallup anketine g\u00f6re ABD'deki yeti\u015fkinlerin yakla\u015f\u0131k y\u00fczde 11'i (yakla\u015f\u0131k 30 milyon ki\u015fi) kilo vermek amac\u0131yla GLP-1 ila\u00e7lar\u0131 kullan\u0131yor. \u00c7al\u0131\u015fmadaki vakalar\u0131n b\u00fcy\u00fck k\u0131sm\u0131, semaglutid i\u00e7eren Ozempic ve Wegovy ya da tirzepatid i\u00e7eren Zepbound (T\u00fcrkiye muadili Mounjaro -ed.n.) gibi GLP-1 ila\u00e7lar\u0131n\u0131 kullanan ki\u015filerde g\u00f6r\u00fcld\u00fc.<\/p>\n
The Independent, yorum almak i\u00e7in ila\u00e7 \u00fcreticileri Novo Nordisk ve Eli Lilly'yle ileti\u015fime ge\u00e7ti. Bulgular, bu ila\u00e7lar\u0131 kullanan ve daha \u015fiddetli gastrointestinal yan etkiler ya\u015fayan hastalar\u0131n Wernicke sendromu a\u00e7\u0131s\u0131ndan artm\u0131\u015f bir risk alt\u0131nda olabilece\u011fini g\u00f6steriyor.<\/p>\n
Bununla birlikte ara\u015ft\u0131rmac\u0131lar, FDA raporlar\u0131n\u0131n s\u00f6zkonusu hastal\u0131\u011fa GLP-1 ila\u00e7lar\u0131n\u0131n yol a\u00e7t\u0131\u011f\u0131n\u0131 kan\u0131tlayamayaca\u011f\u0131na dikkat \u00e7ekti. Bunu do\u011frulamak i\u00e7in daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 var. Ayr\u0131ca bilim insanlar\u0131, hastalar\u0131n yaln\u0131zca bu \u00e7al\u0131\u015fmaya dayanarak kendilerine re\u00e7ete edilen GLP-1 ila\u00e7lar\u0131n\u0131 kullanmay\u0131 b\u0131rakmamas\u0131 gerekti\u011fi konusunda net ifadeler kulland\u0131.<\/p>\n
\u00d6nceki ara\u015ft\u0131rmalar da az say\u0131da GLP-1 ilac\u0131 kullan\u0131c\u0131s\u0131yla bu beyin rahats\u0131zl\u0131\u011f\u0131 aras\u0131nda olas\u0131 ba\u011flant\u0131lar oldu\u011funu ortaya koymu\u015ftu. M\u0131s\u0131r'daki Mansoura \u00dcniversitesi'nden Dr. Manar Kadhem, nisanda yay\u0131mlanan ara\u015ft\u0131rmada, "Hastalar\u0131n sadece kilo vermekle kalmay\u0131p ayn\u0131 zamanda \u015fiddetli gastroparezi ya\u015fad\u0131\u011f\u0131n\u0131 ve s\u00fcrekli kustu\u011funu fark ettik" diye yazm\u0131\u015ft\u0131.<\/p>\n
Wernicke sendromunun yol a\u00e7abilece\u011fi en k\u00f6t\u00fc sonu\u00e7lar\u0131 \u00f6nlemek i\u00e7in acil tedavi gerekiyor. Cleveland Clinic \u015f\u00f6yle a\u00e7\u0131kl\u0131yor: Tiaminle acil tedavi hayati \u00f6nem ta\u015f\u0131r. Bu tedavi semptomlar\u0131 hafifletebilir, ayr\u0131ca haf\u0131za ve di\u011fer beyin fonksiyonlar\u0131nda kal\u0131c\u0131 hasar olu\u015fmas\u0131n\u0131 \u00f6nleyebilir. *\u0130\u00e7erik orijinal haline ba\u011fl\u0131 kal\u0131narak \u00e7evrilmi\u015ftir.<\/p>\n
Independent T\u00fcrk\u00e7e'nin edit\u00f6ryal politikas\u0131n\u0131 yans\u0131tmayabilir Independent T\u00fcrk\u00e7e i\u00e7in \u00e7eviren: \u00c7a\u011fatay Koparal \u00e7eviribeyinzay\u0131flamaWernicke ensefalopatisi kal\u0131c\u0131 haf\u0131za kayb\u0131na yol a\u00e7abiliyorJulia Musto\u00c7ar\u015famba, Eyl\u00fcl 16, 2026 – 10:30<\/p>\n","protected":false},"excerpt":{"rendered":"
Yeni bir ara\u015ft\u0131rma, GLP-1 grubu kilo verme ve diyabet ila\u00e7lar\u0131n\u0131 kullanan ki\u015filerin k\u00fc\u00e7\u00fck bir k\u0131sm\u0131nda, nadir g\u00f6r\u00fclen ciddi bir beyin hastal\u0131\u011f\u0131 tespit edildi\u011fini ortaya koydu. \u0130srail merkezl\u2026<\/p>\n","protected":false},"author":0,"featured_media":157,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,2],"tags":[],"class_list":["post-156","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-casino","category-gundem"],"_links":{"self":[{"href":"https:\/\/alman-bahis-giris.icu\/index.php\/wp-json\/wp\/v2\/posts\/156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alman-bahis-giris.icu\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/alman-bahis-giris.icu\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/alman-bahis-giris.icu\/index.php\/wp-json\/wp\/v2\/comments?post=156"}],"version-history":[{"count":0,"href":"https:\/\/alman-bahis-giris.icu\/index.php\/wp-json\/wp\/v2\/posts\/156\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/alman-bahis-giris.icu\/index.php\/wp-json\/wp\/v2\/media\/157"}],"wp:attachment":[{"href":"https:\/\/alman-bahis-giris.icu\/index.php\/wp-json\/wp\/v2\/media?parent=156"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/alman-bahis-giris.icu\/index.php\/wp-json\/wp\/v2\/categories?post=156"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/alman-bahis-giris.icu\/index.php\/wp-json\/wp\/v2\/tags?post=156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}